Development of an analytical method for simultaneous detection of psychotropic phenylalkylamines in hair by LC-MS/MS with a multi-mode reversed-phase column using pH gradient elution

Highlights • A LC-MS/MS method for psychotropic phenalkylamines analysis in hair was developed. • The developed LC-MS/MS method is analytically equivalent to existing GC–MS methods. • Using the multi-mode reversed-phase column with pH gradient enhanced the sensitivity. • The on-column concentration...

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Veröffentlicht in:	Forensic science international 2016-02, Vol.259, p.69-76
Hauptverfasser:	Choi, Hyeyoung, Kim, Suncheun, Ahn, Suyoun, Chang, Hyejin, Lee, Sangki, Lee, Yongmoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphetamines Chromatography Chromatography, Liquid - methods Chromatography, Reverse-Phase - methods Drug abuse Elution Female Forensic sciences Hair Hair - chemistry Hair analysis Humans Hydrogen-Ion Concentration Ions LC-MS/MS Ligands Linearity Male Mass spectrometry Middle Aged Multi-mode reversed phase column Pathology pH gradient Phenethylamines - analysis Psychotropic Drugs - analysis Psychotropic phenylalkylamines Scientific imaging Slopes Tandem Mass Spectrometry - methods Young Adult
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Zusammenfassung:	Highlights • A LC-MS/MS method for psychotropic phenalkylamines analysis in hair was developed. • The developed LC-MS/MS method is analytically equivalent to existing GC–MS methods. • Using the multi-mode reversed-phase column with pH gradient enhanced the sensitivity. • The on-column concentration could be applied to small quantity of hair samples.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2015.12.016