Steroid-induced glaucoma treated with trabecular ablation in a matched comparison with primary open-angle glaucoma

Background To evaluate the outcomes of trabectome‐mediated ab interno trabeculectomy in patients with steroid‐induced glaucoma (SIG). Design A retrospective, observational cohort study performed in the Department of Ophthalmology, University of Pittsburgh Medical Center. Participants The data of 60 patients with SIG and 484 controls with primary open‐angle glaucoma (POAG) matched by age, gender and glaucoma index were collected from the Trabectome Study Group database. Methods Reduction of intraocular pressure (IOP) and medications were compared between POAG and SIG by multivariate regression. Kaplan–Meier was used for survival analysis. Success was defined as IOP ≤21 mmHg and at least 20% IOP reduction from baseline for any two consecutive visits after 3 months without secondary glaucoma surgery. Postoperative IOP and number of medications were compared with baseline in the SIG subgroups by the Wilcoxon test. Main Outcome Measures Intraocular pressure reduction and 1‐year success rate. Results Patients with SIG had a higher baseline IOP (31.4 ± 10.4 vs. 24.1 ± 7.6 mmHg, P