Cellular Uptake: Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling (Adv. Healthcare Mater. 24/2016)

Cellular Uptake: Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling (Adv. Healthcare Mater. 24/2016)

On page 3118, a new hybrid structure consisting of a cytotoxic 1.4 nm sized gold core surrounded by a fluorophore‐containing ligand shell is designed to monitor cellular uptake by Ulrich Simon and co‐workers. The evolution of fluorescence upon cellular uptake discloses that the loss of the ligand sh...

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Veröffentlicht in:Advanced healthcare materials 2016-12, Vol.5 (24), p.3088-3088
Hauptverfasser: Broda, Janine, Küster, Andrea, Westhues, Stefan, Fahrenkamp, Dirk, Vogg, Andreas T. J., Steitz, Julia, Mottaghy, Felix M., Müller-Newen, Gerhard, Simon, Ulrich
Format: Artikel
Sprache:eng
Schlagworte:
cellular uptake
Cytotoxicity
fluorescence
gold nanoparticles
Ligands
Nanoparticles
TPPMS
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Zusammenfassung:On page 3118, a new hybrid structure consisting of a cytotoxic 1.4 nm sized gold core surrounded by a fluorophore‐containing ligand shell is designed to monitor cellular uptake by Ulrich Simon and co‐workers. The evolution of fluorescence upon cellular uptake discloses that the loss of the ligand shell or of parts of is the essential to unfold high AuNP cytotoxicity.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201670128