Landau–Kleffner Syndrome: Localization of Epileptogenic Lesion Using Wavelet– Cross-Correlation Analysis

Magnetoencephalographic findings in a 6-year-old patient suffering from acquired aphasia with convulsive disorder (Landau–Kleffner Syndrome, LKS) are presented. The data were analyzed using wavelet–cross-correlation analysis, a nonstationary analysis method developed to analyze the localization of an epileptogenic lesion and the propagation of epileptiform discharges. The results indicate that LKS might be a disorder of the primary temporal cortex, and that the auditory neural network may function as the circuit for the epileptic discharge propagation.