From Solutions to Surfaces: A Novel Molecular Imprinting Method Based on the Conformational Changes of Boronic-Acid-Appended Poly(L-lysine)

From Solutions to Surfaces: A Novel Molecular Imprinting Method Based on the Conformational Changes of Boronic-Acid-Appended Poly(L-lysine)

The dominant solution‐phase conformation of a polymer can be fixed to a surface (see scheme). Boronic acid appended poly(L‐lysine) assumes different conformations in the presence of D‐glucose or D‐fructose. When the polymer–glucose complex is anchored to a gold surface, an imprinted interface with “...

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Veröffentlicht in:Angewandte Chemie International Edition 2001-12, Vol.40 (24), p.4729-4731
Hauptverfasser: Friggeri, Arianna, Kobayashi, Hideki, Shinkai, Seiji, Reinhoudt, David N.
Format: Artikel
Sprache:eng
Schlagworte:
carbohydrates
molecular recognition
surface chemistry
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Zusammenfassung:The dominant solution‐phase conformation of a polymer can be fixed to a surface (see scheme). Boronic acid appended poly(L‐lysine) assumes different conformations in the presence of D‐glucose or D‐fructose. When the polymer–glucose complex is anchored to a gold surface, an imprinted interface with “molecular memory” for glucose over fructose can be prepared.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011217)40:24<4729::AID-ANIE4729>3.0.CO;2-M