The effect of sleep deprivation on memory and psychomotor function in healthy volunteers

Benzodiazepines and other psychotropic drugs have been implicated in the production of memory deficits. The mechanism is unclear, but both a distinct pharmacological action and a non‐specific sedative effect have been suggested as being causal or contributory. These two postulated mechanisms of acti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Human psychopharmacology 2000-04, Vol.15 (3), p.171-177
Hauptverfasser: Quigley, N., Green, J. F., Morgan, D., Idzikowski, C., King, D. J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Benzodiazepines and other psychotropic drugs have been implicated in the production of memory deficits. The mechanism is unclear, but both a distinct pharmacological action and a non‐specific sedative effect have been suggested as being causal or contributory. These two postulated mechanisms of action may be examined separately by using sleep deprivation as a method of non‐pharmacological sedation. We measured psychomotor and memory functions in eight sleep‐deprived healthy volunteers and eight controls. There was both subjective and objective evidence of sedation, but memory function was not affected. These findings support the view that the effect on memory of psychotropic drugs is principally caused by a direct amnestic effect rather than by drug‐induced sedation. Copyright © 2000 John Wiley & Sons, Ltd.
ISSN:0885-6222
1099-1077
DOI:10.1002/(SICI)1099-1077(200004)15:3<171::AID-HUP155>3.0.CO;2-D