Clinic Dosing of β Blockers in Chronic Heart Failure
Beta blockers improve survival and reduce morbidity of patients with chronic heart failure. Stringent dosing guidelines calling for a 1‐hour observation period after initiation or up‐titration of β‐blocker therapy might limit the use of β blockers and increase the expense involved. This study was co...
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Veröffentlicht in: | Congestive heart failure (Greenwich, Conn.) Conn.), 2001-07, Vol.7 (4), p.196-200 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Beta blockers improve survival and reduce morbidity of patients with chronic heart failure. Stringent dosing guidelines calling for a 1‐hour observation period after initiation or up‐titration of β‐blocker therapy might limit the use of β blockers and increase the expense involved. This study was conducted to determine the usefulness of this observation period. Data were collected from 130 inclinic postdosing observation periods for 34 stable chronic heart failure patients started on carvedilol. The mean left ventricular ejection fraction was 0.22±0.09, and the mean functional class was 2.5±0.6. No patient had greater than first‐degree heart block. Carvedilol was started at 3.125 or 6.25 mg b.i.d., and the dose was doubled every 1–3 weeks. All patients were observed for 1–2 hours after initiation or dosage increase, and blood pressure and heart rate were measured hourly. The maximal daily dose was 50±31 mg. In none of the observation periods was there a decrease in the dose of β blockers administered in the clinic. The predosing mean blood pressure was 110±15/71±10 mm Hg, and the mean heart rate was 78±13 bpm; the 1‐hour postdosing mean blood pressure was 101±14/67±10 mm Hg (p |
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ISSN: | 1527-5299 1751-7133 |
DOI: | 10.1111/j.1527-5299.2001.00253.x |