Phomacins:  Three Novel Antitumor Cytochalasan Constituents Produced by a Phoma sp

Phomacins:  Three Novel Antitumor Cytochalasan Constituents Produced by a Phoma sp

Three novel cytochalasans, phomacins A, B and C, were isolated from a fermentation broth of the fungus Phoma sp. and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by 1D and 2D NMR techniques. All three compounds have shown potent inhibi...

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Veröffentlicht in:Journal of organic chemistry 1997-04, Vol.62 (7), p.2148-2151
Hauptverfasser: Alvi, Khisal A, Nair, Bipin, Pu, Henry, Ursino, Rocky, Gallo, Cathy, Mocek, Ursula
Format: Artikel
Sprache:eng
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Zusammenfassung:Three novel cytochalasans, phomacins A, B and C, were isolated from a fermentation broth of the fungus Phoma sp. and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by 1D and 2D NMR techniques. All three compounds have shown potent inhibitory activity against the HT29 colonic adenocarcinoma cell line.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo962321s