Deracemization of racemic 4-pyridyl-1-ethanol by Catharanthus roseus cell cultures

Immobilized cells of Catharanthus roseus synthesized ( R)-4-pyridyl-1-ethanol from the corresponding racemate in 100% yield by stereoinversion of the ( S)-alcohol in the racemate to the ( R)-alcohol. Furthermore, in the reduction of 4-acetylpyridine, we could synthesize both ( R) and ( S)-4-pyridyl-...

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Veröffentlicht in:	Phytochemistry (Oxford) 1998-11, Vol.49 (6), p.1627-1629
Hauptverfasser:	Takemoto, Masumi, Achiwa, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apocynaceae Biological and medical sciences Biotechnology Catharanthus roseus cell cultures chiral 4-pyridyl-1-ethanol Fundamental and applied biological sciences. Psychology Immobilization of organelles and whole cells Immobilization techniques Methods. Procedures. Technologies reduction stereoinversion
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Zusammenfassung:	Immobilized cells of Catharanthus roseus synthesized ( R)-4-pyridyl-1-ethanol from the corresponding racemate in 100% yield by stereoinversion of the ( S)-alcohol in the racemate to the ( R)-alcohol. Furthermore, in the reduction of 4-acetylpyridine, we could synthesize both ( R) and ( S)-4-pyridyl-1-ethanol during a short or a long incubation.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(98)00241-6