Different effects of conjugated linoleic acid isomers on lipoprotein lipase activity in 3T3-L1 adipocytes

Conjugated linoleic acids (CLAs) are the positional and geometric isomers of linoleic acid. In the present study the effects of cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA ) on intracellular and heparin-releasable (HR-) lipoprotein lipase (LPL) activity in 3T3-L1 adipocyte...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2001-03, Vol.12 (3), p.183-189
Hauptverfasser:	Lin, Yuguang, Kreeft, Arja, Schuurbiers, Johan A.E, Draijer, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 L1 adipocytes Biological and medical sciences Conjugated linoleic acid Fatty acids Fundamental and applied biological sciences. Psychology Lipoprotein lipase Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Beschreibung
Zusammenfassung:	Conjugated linoleic acids (CLAs) are the positional and geometric isomers of linoleic acid. In the present study the effects of cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA ) on intracellular and heparin-releasable (HR-) lipoprotein lipase (LPL) activity in 3T3-L1 adipocytes were investigated. Cells were exposed to the two CLA isomers and linoleic acid, which were bound to bovine serum albumin (BSA). In the adipocytes insulin up-regulated and tumor necrosis factor alpha (TNFα) down-regulated HR-LPL activity, which corresponds with the findings in vivo. The experimental fatty acids at low concentrations (
ISSN:	0955-2863 1873-4847
DOI:	10.1016/S0955-2863(00)00155-8