The use of citalopram in resistant cataplexy

Background: Cataplexy is a disabling component of the narcolepsy tetrad that is sometimes resistant to standard treatment. Case reports: Three of our patients with narcolepsy, including one who had post-traumatic narcolepsy, suffered from intractable cataplexy with failure of treatment with established drugs due to unacceptable side-effects. Results: We explored the use of citalopram (Celexa), the newest and most specific of the serotonin reuptake inhibitors, and were successful in treating cataplexy without significant side-effects. Stimulant drugs remained necessary for controlling symptoms of excessive drowsiness. Conclusions: Citalopram was effective in relieving the symptoms of resistant cataplexy in out patients.