The effects of chronic hepatitis C and B virus infections on liver reduced and oxidized glutathione concentrations
The aim of this study was to evaluate the effects of hepatitis B and C virus infections on liver glutathione status. Reduced and oxidized glutathione levels were determined in liver biopsy specimens obtained from patients with chronic liver disease including chronic active hepatitis and cirrhosis. I...
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| Veröffentlicht in: | Hepatology research 2000-08, Vol.18 (2), p.104-109 |
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| container_title | Hepatology research |
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| creator | Tanyalcin, Tijen Taskiran, Dilek Topalak, Omer Batur, Yucel Kutay, Fatma |
| description | The aim of this study was to evaluate the effects of hepatitis B and C virus infections on liver glutathione status. Reduced and oxidized glutathione levels were determined in liver biopsy specimens obtained from patients with chronic liver disease including chronic active hepatitis and cirrhosis. In patients with hepatitis B virus infections, GSH and GSH/GSSG levels were significantly low compared with those in controls (
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| doi_str_mv | 10.1016/S1386-6346(99)00088-1 |
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P<0.01). There was a significant negative correlation between histological activity indices (HAI) and hepatic GSSG levels only in patients with chronic HCV infection (
P<0.01;
r=−0.895). In addition to this, we also found a positive correlation between indices (HAI) and GSH/GSSG of the same group (
r=0.915;
P<0.05). These observations suggest that HBV and HCV infections have different effects on liver glutathione status based on diverse mechanisms.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1016/S1386-6346(99)00088-1</identifier><identifier>PMID: 10936561</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Chronic hepatitis ; Glutathione ; Human viral diseases ; Infectious diseases ; Liver ; Medical sciences ; Viral diseases ; Viral hepatitis</subject><ispartof>Hepatology research, 2000-08, Vol.18 (2), p.104-109</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-21bfe197a8c856c8fd352761fd722255bc296d711b060cab35238a5e88578b03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1421047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10936561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanyalcin, Tijen</creatorcontrib><creatorcontrib>Taskiran, Dilek</creatorcontrib><creatorcontrib>Topalak, Omer</creatorcontrib><creatorcontrib>Batur, Yucel</creatorcontrib><creatorcontrib>Kutay, Fatma</creatorcontrib><title>The effects of chronic hepatitis C and B virus infections on liver reduced and oxidized glutathione concentrations</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>The aim of this study was to evaluate the effects of hepatitis B and C virus infections on liver glutathione status. Reduced and oxidized glutathione levels were determined in liver biopsy specimens obtained from patients with chronic liver disease including chronic active hepatitis and cirrhosis. In patients with hepatitis B virus infections, GSH and GSH/GSSG levels were significantly low compared with those in controls (
P<0.01). There was a significant negative correlation between histological activity indices (HAI) and hepatic GSSG levels only in patients with chronic HCV infection (
P<0.01;
r=−0.895). In addition to this, we also found a positive correlation between indices (HAI) and GSH/GSSG of the same group (
r=0.915;
P<0.05). These observations suggest that HBV and HCV infections have different effects on liver glutathione status based on diverse mechanisms.</description><subject>Biological and medical sciences</subject><subject>Chronic hepatitis</subject><subject>Glutathione</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Liver</subject><subject>Medical sciences</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkEuPFCEURonROA_9CRoWLmYWpTyKR63M2PGVTOLCXrgjFFxsTDW0UNVRf730w-jO1eWG8_GRg9AzSl5SQuWrz5Rr2Uney5thuCWEaN3RB-iSasU6wvsvD9v5D3KBrmr9RghVhPWP0QUlA5dC0ktU1hvAEAK4ueIcsNuUnKLDG9jZOc6x4hW2yeM3eB_LUnFMBzTm1OiEp7iHggv4xYE_cvlH9PFXW75Oy2znTSMBu5wcpLnYY_AJehTsVOHpeV6j9bu369WH7v7T-4-ru_vO9ULPHaNjADooq50W0unguWBK0uAVY0yI0bFBekXpSCRxdmy3XFsBWgulR8Kv0c3p2V3J3xeos9nG6mCabIK8VEO1GDhniquGihPqSq61QDC7Ere2_DSUmINtc7RtDirNMJijbUNb7vm5Yhm34P9JnfQ24MUZsNXZKRSbXKx_uZ5R0h_6X58waDr2EYqpLkJz5mNpto3P8T8_-Q16wJxw</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Tanyalcin, Tijen</creator><creator>Taskiran, Dilek</creator><creator>Topalak, Omer</creator><creator>Batur, Yucel</creator><creator>Kutay, Fatma</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>The effects of chronic hepatitis C and B virus infections on liver reduced and oxidized glutathione concentrations</title><author>Tanyalcin, Tijen ; Taskiran, Dilek ; Topalak, Omer ; Batur, Yucel ; Kutay, Fatma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-21bfe197a8c856c8fd352761fd722255bc296d711b060cab35238a5e88578b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Chronic hepatitis</topic><topic>Glutathione</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>Liver</topic><topic>Medical sciences</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanyalcin, Tijen</creatorcontrib><creatorcontrib>Taskiran, Dilek</creatorcontrib><creatorcontrib>Topalak, Omer</creatorcontrib><creatorcontrib>Batur, Yucel</creatorcontrib><creatorcontrib>Kutay, Fatma</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanyalcin, Tijen</au><au>Taskiran, Dilek</au><au>Topalak, Omer</au><au>Batur, Yucel</au><au>Kutay, Fatma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of chronic hepatitis C and B virus infections on liver reduced and oxidized glutathione concentrations</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>18</volume><issue>2</issue><spage>104</spage><epage>109</epage><pages>104-109</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>The aim of this study was to evaluate the effects of hepatitis B and C virus infections on liver glutathione status. Reduced and oxidized glutathione levels were determined in liver biopsy specimens obtained from patients with chronic liver disease including chronic active hepatitis and cirrhosis. In patients with hepatitis B virus infections, GSH and GSH/GSSG levels were significantly low compared with those in controls (
P<0.01). There was a significant negative correlation between histological activity indices (HAI) and hepatic GSSG levels only in patients with chronic HCV infection (
P<0.01;
r=−0.895). In addition to this, we also found a positive correlation between indices (HAI) and GSH/GSSG of the same group (
r=0.915;
P<0.05). These observations suggest that HBV and HCV infections have different effects on liver glutathione status based on diverse mechanisms.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10936561</pmid><doi>10.1016/S1386-6346(99)00088-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Hepatology research, 2000-08, Vol.18 (2), p.104-109 |
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| source | Alma/SFX Local Collection |
| subjects | Biological and medical sciences Chronic hepatitis Glutathione Human viral diseases Infectious diseases Liver Medical sciences Viral diseases Viral hepatitis |
| title | The effects of chronic hepatitis C and B virus infections on liver reduced and oxidized glutathione concentrations |
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