Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease
We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 cont...
Gespeichert in:
| Veröffentlicht in: | Parkinsonism & related disorders 2000-10, Vol.6 (4), p.195-197 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 197 |
|---|---|
| container_issue | 4 |
| container_start_page | 195 |
| container_title | Parkinsonism & related disorders |
| container_volume | 6 |
| creator | Zhang, J Hattori, N Leroy, E Morris, H.R Kubo, S.-I Kobayashi, T Wood, N.W Polymeropoulos, M.H Mizuno, Y |
| description | We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 control subjects (Japanese and Caucasians). The frequency of the mutant allele (Y) was significantly higher in Japanese control subjects (51.2%) than in Japanese PD patients (43.4%) (
χ
2=3.917,
p=0.048 |
| doi_str_mv | 10.1016/S1353-8020(00)00015-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859331370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1353802000000158</els_id><sourcerecordid>1859331370</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-a940719351930aeb992857be3452b9e9cd8fdcd9b85ab812f09443bb15d937603</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1ERT_gJ4B8Y3sIjON4Y59QVUFBWqlI0LPljwk1JHZqJ9CV-PEkbCtxQ_LIc3jeGc1DyEsGbxiw7dsvjAteSahhA3AOAExU8gk5YbLllWD19unSPyLH5LSU7wvUCuDPyDEDBcBVfUJ-X5SSXDBTSJFanH4hRmromPr9kPJ4G8pAU0dnG-7mMIVInck23e-rCfMQounp7d7n1JuCdMfo5ubyY7Vj5_QbRqQmelrGlI0Pjn42-UeIJcXXhfpQcEk8J0ed6Qu-ePjPyM2H91_XCddXny4vdpVrajVVRjXQMsXFUmDQKlVL0VrkjaitQuW87LzzykphrGR1B6ppuLVMeMXbLfAzsjnMHXO6m7FMegjFYd-biGkumkmhOGe8XVFxQF1OpWTs9JjDYPJeM9CreP1XvF6taljfIl7LJffqYcVsB_T_pA6mF-DdAcDl0J8Bsy4uYHToQ0Y3aZ_Cf1b8AS3EkoE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859331370</pqid></control><display><type>article</type><title>Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease</title><source>Access via ScienceDirect (Elsevier)</source><creator>Zhang, J ; Hattori, N ; Leroy, E ; Morris, H.R ; Kubo, S.-I ; Kobayashi, T ; Wood, N.W ; Polymeropoulos, M.H ; Mizuno, Y</creator><creatorcontrib>Zhang, J ; Hattori, N ; Leroy, E ; Morris, H.R ; Kubo, S.-I ; Kobayashi, T ; Wood, N.W ; Polymeropoulos, M.H ; Mizuno, Y</creatorcontrib><description>We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 control subjects (Japanese and Caucasians). The frequency of the mutant allele (Y) was significantly higher in Japanese control subjects (51.2%) than in Japanese PD patients (43.4%) (
χ
2=3.917,
p=0.048<0.05). It appears that this polymorphism has a weak protective factor against PD in at least the Japanese population. The frequencies of Y allele and S/Y and Y/Y genotypes in the PD patients and the controls were more significantly higher in Japanese than in Caucasian population (
p<0.0001). It seems that the role of this polymorphism in PD may be different between Caucasian and Japanese populations.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/S1353-8020(00)00015-8</identifier><identifier>PMID: 10900392</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Association study ; Lewy bodies ; Parkinson's disease ; Polymorphism ; Ubiquitin carboxy-terminal hydrolase L1 gene</subject><ispartof>Parkinsonism & related disorders, 2000-10, Vol.6 (4), p.195-197</ispartof><rights>2000 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-a940719351930aeb992857be3452b9e9cd8fdcd9b85ab812f09443bb15d937603</citedby><cites>FETCH-LOGICAL-c429t-a940719351930aeb992857be3452b9e9cd8fdcd9b85ab812f09443bb15d937603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1353-8020(00)00015-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10900392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Hattori, N</creatorcontrib><creatorcontrib>Leroy, E</creatorcontrib><creatorcontrib>Morris, H.R</creatorcontrib><creatorcontrib>Kubo, S.-I</creatorcontrib><creatorcontrib>Kobayashi, T</creatorcontrib><creatorcontrib>Wood, N.W</creatorcontrib><creatorcontrib>Polymeropoulos, M.H</creatorcontrib><creatorcontrib>Mizuno, Y</creatorcontrib><title>Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 control subjects (Japanese and Caucasians). The frequency of the mutant allele (Y) was significantly higher in Japanese control subjects (51.2%) than in Japanese PD patients (43.4%) (
χ
2=3.917,
p=0.048<0.05). It appears that this polymorphism has a weak protective factor against PD in at least the Japanese population. The frequencies of Y allele and S/Y and Y/Y genotypes in the PD patients and the controls were more significantly higher in Japanese than in Caucasian population (
p<0.0001). It seems that the role of this polymorphism in PD may be different between Caucasian and Japanese populations.</description><subject>Association study</subject><subject>Lewy bodies</subject><subject>Parkinson's disease</subject><subject>Polymorphism</subject><subject>Ubiquitin carboxy-terminal hydrolase L1 gene</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi1ERT_gJ4B8Y3sIjON4Y59QVUFBWqlI0LPljwk1JHZqJ9CV-PEkbCtxQ_LIc3jeGc1DyEsGbxiw7dsvjAteSahhA3AOAExU8gk5YbLllWD19unSPyLH5LSU7wvUCuDPyDEDBcBVfUJ-X5SSXDBTSJFanH4hRmromPr9kPJ4G8pAU0dnG-7mMIVInck23e-rCfMQounp7d7n1JuCdMfo5ubyY7Vj5_QbRqQmelrGlI0Pjn42-UeIJcXXhfpQcEk8J0ed6Qu-ePjPyM2H91_XCddXny4vdpVrajVVRjXQMsXFUmDQKlVL0VrkjaitQuW87LzzykphrGR1B6ppuLVMeMXbLfAzsjnMHXO6m7FMegjFYd-biGkumkmhOGe8XVFxQF1OpWTs9JjDYPJeM9CreP1XvF6taljfIl7LJffqYcVsB_T_pA6mF-DdAcDl0J8Bsy4uYHToQ0Y3aZ_Cf1b8AS3EkoE</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Zhang, J</creator><creator>Hattori, N</creator><creator>Leroy, E</creator><creator>Morris, H.R</creator><creator>Kubo, S.-I</creator><creator>Kobayashi, T</creator><creator>Wood, N.W</creator><creator>Polymeropoulos, M.H</creator><creator>Mizuno, Y</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease</title><author>Zhang, J ; Hattori, N ; Leroy, E ; Morris, H.R ; Kubo, S.-I ; Kobayashi, T ; Wood, N.W ; Polymeropoulos, M.H ; Mizuno, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-a940719351930aeb992857be3452b9e9cd8fdcd9b85ab812f09443bb15d937603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Association study</topic><topic>Lewy bodies</topic><topic>Parkinson's disease</topic><topic>Polymorphism</topic><topic>Ubiquitin carboxy-terminal hydrolase L1 gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Hattori, N</creatorcontrib><creatorcontrib>Leroy, E</creatorcontrib><creatorcontrib>Morris, H.R</creatorcontrib><creatorcontrib>Kubo, S.-I</creatorcontrib><creatorcontrib>Kobayashi, T</creatorcontrib><creatorcontrib>Wood, N.W</creatorcontrib><creatorcontrib>Polymeropoulos, M.H</creatorcontrib><creatorcontrib>Mizuno, Y</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, J</au><au>Hattori, N</au><au>Leroy, E</au><au>Morris, H.R</au><au>Kubo, S.-I</au><au>Kobayashi, T</au><au>Wood, N.W</au><au>Polymeropoulos, M.H</au><au>Mizuno, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>6</volume><issue>4</issue><spage>195</spage><epage>197</epage><pages>195-197</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 control subjects (Japanese and Caucasians). The frequency of the mutant allele (Y) was significantly higher in Japanese control subjects (51.2%) than in Japanese PD patients (43.4%) (
χ
2=3.917,
p=0.048<0.05). It appears that this polymorphism has a weak protective factor against PD in at least the Japanese population. The frequencies of Y allele and S/Y and Y/Y genotypes in the PD patients and the controls were more significantly higher in Japanese than in Caucasian population (
p<0.0001). It seems that the role of this polymorphism in PD may be different between Caucasian and Japanese populations.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10900392</pmid><doi>10.1016/S1353-8020(00)00015-8</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1353-8020 |
| ispartof | Parkinsonism & related disorders, 2000-10, Vol.6 (4), p.195-197 |
| issn | 1353-8020 1873-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859331370 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Association study Lewy bodies Parkinson's disease Polymorphism Ubiquitin carboxy-terminal hydrolase L1 gene |
| title | Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T14%3A39%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20a%20polymorphism%20of%20ubiquitin%20carboxy-terminal%20hydrolase%20L1%20(UCH-L1)%20gene%20and%20sporadic%20Parkinson's%20disease&rft.jtitle=Parkinsonism%20&%20related%20disorders&rft.au=Zhang,%20J&rft.date=2000-10-01&rft.volume=6&rft.issue=4&rft.spage=195&rft.epage=197&rft.pages=195-197&rft.issn=1353-8020&rft.eissn=1873-5126&rft_id=info:doi/10.1016/S1353-8020(00)00015-8&rft_dat=%3Cproquest_cross%3E1859331370%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859331370&rft_id=info:pmid/10900392&rft_els_id=S1353802000000158&rfr_iscdi=true |