Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease

Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease

We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 cont...

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Veröffentlicht in:Parkinsonism & related disorders 2000-10, Vol.6 (4), p.195-197
Hauptverfasser: Zhang, J, Hattori, N, Leroy, E, Morris, H.R, Kubo, S.-I, Kobayashi, T, Wood, N.W, Polymeropoulos, M.H, Mizuno, Y
Format: Artikel
Sprache:eng
Schlagworte:
Association study
Lewy bodies
Parkinson's disease
Polymorphism
Ubiquitin carboxy-terminal hydrolase L1 gene
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Zusammenfassung:We found a novel polymorphism (S/Y18) of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene a mutation of which is expected to contribute to the etiology of a form of familial Parkinson's disease (PD). We report the frequency of this polymorphism in 313 patients with sporadic PD and 302 control subjects (Japanese and Caucasians). The frequency of the mutant allele (Y) was significantly higher in Japanese control subjects (51.2%) than in Japanese PD patients (43.4%) ( χ 2=3.917, p=0.048
ISSN:1353-8020
1873-5126
DOI:10.1016/S1353-8020(00)00015-8