Synthesis of 3-Ethoxycarbonyl-4-hydroxyquinoline N-Oxides from the Baylis−Hillman Adducts of o-Nitrobenzaldehydes

Synthesis of 3-Ethoxycarbonyl-4-hydroxyquinoline N-Oxides from the Baylis−Hillman Adducts of o-Nitrobenzaldehydes

The reaction of the Baylis−Hillman adducts 1a − e of o-nitrobenzaldehydes and trifluoroacetic acid at 60−70 °C gave 3-ethoxycarbonyl-4-hydroxyquinoline N-oxide derivatives 3a − e in good to moderate yields.

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Veröffentlicht in:Organic letters 2000-02, Vol.2 (3), p.343-345
Hauptverfasser: Kim, Jae Nyoung, Lee, Ka Young, Kim, Hyoung Shik, Kim, Tae Yi
Format: Artikel
Sprache:eng
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Zusammenfassung:The reaction of the Baylis−Hillman adducts 1a − e of o-nitrobenzaldehydes and trifluoroacetic acid at 60−70 °C gave 3-ethoxycarbonyl-4-hydroxyquinoline N-oxide derivatives 3a − e in good to moderate yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol9903741