Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions
Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature ( T c)=41.5, 42, or 42.6°C) rats. Following attainment of the target T c, Evans blue (Eb) was administered via jugular cannula; the animals were anes...
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| Veröffentlicht in: | Journal of thermal biology 2000-10, Vol.25 (5), p.381-386 |
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| container_title | Journal of thermal biology |
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| creator | Matthew, Candace B. DuBose, David A. Sils, Ingrid V. Tartartini, Kimberly A. |
| description | Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature (
T
c)=41.5, 42, or 42.6°C) rats. Following attainment of the target
T
c, Evans blue (Eb) was administered via jugular cannula; the animals were anesthetized, exsanguinated, tissues removed and washed in saline, and Eb extracted with formamide. There was significantly (
p |
| doi_str_mv | 10.1016/S0306-4565(99)00110-2 |
| format | Article |
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T
c)=41.5, 42, or 42.6°C) rats. Following attainment of the target
T
c, Evans blue (Eb) was administered via jugular cannula; the animals were anesthetized, exsanguinated, tissues removed and washed in saline, and Eb extracted with formamide. There was significantly (
p<0.05) more Eb (μg/g of dry wt of tissue, mean±SD) in the tissues of severely hyperthermic (
T
c=42.6°C) rats vs that of control rats: liver — 198±39 vs 125±28, kidney — 376±68 vs 176±60, and small intestine — 170±49 vs 106±20. This model may be useful in evaluating the efficacy of treatment modalities designed to sustain vascular integrity in the face of environmental insult.</description><identifier>ISSN: 0306-4565</identifier><identifier>EISSN: 1879-0992</identifier><identifier>DOI: 10.1016/S0306-4565(99)00110-2</identifier><identifier>PMID: 10838177</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animal ; Core temperature ; Endothelium ; Evans blue ; Extravasation ; Hyperthermia ; Rats ; Thermoregulation ; Vascular permeability</subject><ispartof>Journal of thermal biology, 2000-10, Vol.25 (5), p.381-386</ispartof><rights>1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-4d54b4519ca9fd8c079ae6fbf81e80905d30c431ae24bbfc895c450f81faef1a3</citedby><cites>FETCH-LOGICAL-c363t-4d54b4519ca9fd8c079ae6fbf81e80905d30c431ae24bbfc895c450f81faef1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306456599001102$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10838177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matthew, Candace B.</creatorcontrib><creatorcontrib>DuBose, David A.</creatorcontrib><creatorcontrib>Sils, Ingrid V.</creatorcontrib><creatorcontrib>Tartartini, Kimberly A.</creatorcontrib><title>Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions</title><title>Journal of thermal biology</title><addtitle>J Therm Biol</addtitle><description>Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature (
T
c)=41.5, 42, or 42.6°C) rats. Following attainment of the target
T
c, Evans blue (Eb) was administered via jugular cannula; the animals were anesthetized, exsanguinated, tissues removed and washed in saline, and Eb extracted with formamide. There was significantly (
p<0.05) more Eb (μg/g of dry wt of tissue, mean±SD) in the tissues of severely hyperthermic (
T
c=42.6°C) rats vs that of control rats: liver — 198±39 vs 125±28, kidney — 376±68 vs 176±60, and small intestine — 170±49 vs 106±20. This model may be useful in evaluating the efficacy of treatment modalities designed to sustain vascular integrity in the face of environmental insult.</description><subject>Animal</subject><subject>Core temperature</subject><subject>Endothelium</subject><subject>Evans blue</subject><subject>Extravasation</subject><subject>Hyperthermia</subject><subject>Rats</subject><subject>Thermoregulation</subject><subject>Vascular permeability</subject><issn>0306-4565</issn><issn>1879-0992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkE1PGzEQhq2qCALlJ7TyMRy22Ov1rt1LhVALSJE4QM_WrHfcuNqP1PZG5N_jkKjqjdMc5nnf0TyEfObsK2e8vn5igtVFJWu51PqKMc5ZUX4gC64aXTCty49k8Q85I-cx_smQFJKdkjPOlFC8aRZke7_bYEhrDIOHwo_dbLGjdg3jb4zUjzSv6BainXsINKMDQut7n3Z0cjRAit8o0GHqsKdxFxMONE0UX2DwI-7DATY4J29zV8KwxTH5aYyfyImDPuLlcV6QXz9_PN_eF6vHu4fbm1VhRS1SUXWyaivJtQXtOmVZowFr1zrFUTHNZCeYrQQHLKu2dVZpaSvJ8toBOg7igiwPvZsw_Z0xJjP4aLHvYcRpjoYrqUVZNqrJqDygNkwxBnRmE_wAYWc4M3vl5k252fs0Wps35abMuS_HE3M7YPdf6uA4A98PAOZHtx6DidbjmD37gDaZbvLvnHgF0iOTqA</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Matthew, Candace B.</creator><creator>DuBose, David A.</creator><creator>Sils, Ingrid V.</creator><creator>Tartartini, Kimberly A.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions</title><author>Matthew, Candace B. ; DuBose, David A. ; Sils, Ingrid V. ; Tartartini, Kimberly A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-4d54b4519ca9fd8c079ae6fbf81e80905d30c431ae24bbfc895c450f81faef1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animal</topic><topic>Core temperature</topic><topic>Endothelium</topic><topic>Evans blue</topic><topic>Extravasation</topic><topic>Hyperthermia</topic><topic>Rats</topic><topic>Thermoregulation</topic><topic>Vascular permeability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matthew, Candace B.</creatorcontrib><creatorcontrib>DuBose, David A.</creatorcontrib><creatorcontrib>Sils, Ingrid V.</creatorcontrib><creatorcontrib>Tartartini, Kimberly A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thermal biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matthew, Candace B.</au><au>DuBose, David A.</au><au>Sils, Ingrid V.</au><au>Tartartini, Kimberly A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions</atitle><jtitle>Journal of thermal biology</jtitle><addtitle>J Therm Biol</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>25</volume><issue>5</issue><spage>381</spage><epage>386</epage><pages>381-386</pages><issn>0306-4565</issn><eissn>1879-0992</eissn><abstract>Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature (
T
c)=41.5, 42, or 42.6°C) rats. Following attainment of the target
T
c, Evans blue (Eb) was administered via jugular cannula; the animals were anesthetized, exsanguinated, tissues removed and washed in saline, and Eb extracted with formamide. There was significantly (
p<0.05) more Eb (μg/g of dry wt of tissue, mean±SD) in the tissues of severely hyperthermic (
T
c=42.6°C) rats vs that of control rats: liver — 198±39 vs 125±28, kidney — 376±68 vs 176±60, and small intestine — 170±49 vs 106±20. This model may be useful in evaluating the efficacy of treatment modalities designed to sustain vascular integrity in the face of environmental insult.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10838177</pmid><doi>10.1016/S0306-4565(99)00110-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4565 |
| ispartof | Journal of thermal biology, 2000-10, Vol.25 (5), p.381-386 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Animal Core temperature Endothelium Evans blue Extravasation Hyperthermia Rats Thermoregulation Vascular permeability |
| title | Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions |
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