Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions

Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions

Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature ( T c)=41.5, 42, or 42.6°C) rats. Following attainment of the target T c, Evans blue (Eb) was administered via jugular cannula; the animals were anes...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of thermal biology 2000-10, Vol.25 (5), p.381-386
Hauptverfasser: Matthew, Candace B., DuBose, David A., Sils, Ingrid V., Tartartini, Kimberly A.
Format: Artikel
Sprache:eng
Schlagworte:
Animal
Core temperature
Endothelium
Evans blue
Extravasation
Hyperthermia
Rats
Thermoregulation
Vascular permeability
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature ( T c)=41.5, 42, or 42.6°C) rats. Following attainment of the target T c, Evans blue (Eb) was administered via jugular cannula; the animals were anesthetized, exsanguinated, tissues removed and washed in saline, and Eb extracted with formamide. There was significantly ( p
ISSN:0306-4565
1879-0992
DOI:10.1016/S0306-4565(99)00110-2