Derivatization for electrospray ionization-mass spectrometry. 4. Alkenes and alkynes

A survey of derivatization strategies and prospective derivatization reactions for conversion of simple alkenes and alkynes to ‘electrospray‐active’ species is presented. General synthetic strategies are discussed and illustrative examples of prospective derivatives prepared from model compounds are presented along with their electrospray ionization (ES) mass spectra. The identified derivatives of these neutral, nonpolar analytes are either ionic or are ionizable in solution through Brønsted acid/base chemistry, by Lewis acid/base chemistry, or by chemical or electrochemical electron‐transfer chemistry. Once ionized, the derivatives are expected to be amenable to detection by electrospray ionization‐mass spectrometry. Derivatives are identified for positive and negative ion analysis of both alkenes and alkynes. Copyright © 2000 John Wiley & Sons, Ltd.