Origin of mass shifts in the quadrupole ion trap: dissociation of fragile ions observed with a hybrid ion trap/mass filter instrument

A novel hybrid tandem mass analyzer, coupling a quadrupole ion trap with a quadrupole mass filter, has been constructed to permit mass analysis of ions ejected from the ion trap. The initial application of this instrument is the investigation of the origin of mass shifts in the ion trap due to ion f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Rapid communications in mass spectrometry 2000-01, Vol.14 (4), p.270-273
Hauptverfasser: Murphy III, James Patrick, Yost, Richard A.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A novel hybrid tandem mass analyzer, coupling a quadrupole ion trap with a quadrupole mass filter, has been constructed to permit mass analysis of ions ejected from the ion trap. The initial application of this instrument is the investigation of the origin of mass shifts in the ion trap due to ion fragility. We hypothesize that fragile ions undergo mass shifts, characterized by peak fronting, due to early ejection from the quadrupole ion trap. As these ions come into resonance with the ejection frequency, they gain kinetic energy, collide with buffer gas molecules and thus can dissociate to produce fragment ions. These fragment ions will not be stable within the ion trap as they are situated past the stability boundary at qz = 0.908. Consequently the fragment ions are ejected prematurely. This results in an apparent mass shift due to peak fronting. The experiments reported here clearly document the production of fragment ions as the origin of mass shifts during the resonant ejection of fragile ions. Copyright © 2000 John Wiley & Sons, Ltd.
ISSN:0951-4198
1097-0231
DOI:10.1002/(SICI)1097-0231(20000229)14:4<270::AID-RCM875>3.0.CO;2-6