Facile, Novel Methodology for the Synthesis of Spiro

Facile, Novel Methodology for the Synthesis of Spiro

The role of the bifunctional catalyst is decisive: The magnesium ion as Lewis acid and its nucleophilic iodide counterion contribute in synergy to the successful ring expansion of the cyclopropane 1 by aldimine 2 [Eq. (1)]. This reaction offers a novel route to spiro[pyrrolidin-3,3'-oxindoles]...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-11, Vol.38 (21), p.3186-3189
Hauptverfasser: Alper, PB, Meyers, C, Lerchner, A, Siegel, DR, Carreira, EM
Format: Artikel
Sprache:eng
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Zusammenfassung:The role of the bifunctional catalyst is decisive: The magnesium ion as Lewis acid and its nucleophilic iodide counterion contribute in synergy to the successful ring expansion of the cyclopropane 1 by aldimine 2 [Eq. (1)]. This reaction offers a novel route to spiro[pyrrolidin-3,3'-oxindoles] 3.
ISSN:1521-3773