α-Alkyl-α-Amino-β-Lactam Peptides: Design, Synthesis, and Conformational Features

α-Alkyl-α-Amino-β-Lactam Peptides: Design, Synthesis, and Conformational Features

Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the β‐lactam 1. This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints.

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Veröffentlicht in:Angewandte Chemie International Edition 1999-10, Vol.38 (20), p.3056-3058
Hauptverfasser: Palomo, Claudio, Aizpurua, Jesus M., Benito, Ana, Galarza, Regina, Khamrai, Uttam K., Vazquez, Jordi, de Pascual-Teresa, Beatriz, Nieto, Pedro M., Linden, Anthony
Format: Artikel
Sprache:eng
Schlagworte:
Alkylations
Conformation analysis
Lactams
Peptides
Peptidomimetics
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Beschreibung
Zusammenfassung:Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the β‐lactam 1. This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19991018)38:20<3056::AID-ANIE3056>3.0.CO;2-J