Proline-Based P,N Ligands in Palladium-Catalyzed Asymmetric π-Allyl Additions

Proline-Based P,N Ligands in Palladium-Catalyzed Asymmetric π-Allyl Additions

Excellent yields and at least 95 % ee can be achieved for the addition of dimethyl malonate to cycloalkenyl acetates by using a palladium complex of the new phosphanyldihydrooxazole ligand L as a catalyst (see scheme). The ligand L can be synthesized from commercially available trans 4‐hydroxy‐L‐pro...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-09, Vol.38 (18), p.2750-2752
Hauptverfasser: Gilbertson, Scott R., Xie, Dejian
Format: Artikel
Sprache:eng
Schlagworte:
Alkylations
Asymmetric catalysis
N ligands
P,N ligands
Palladium
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Beschreibung
Zusammenfassung:Excellent yields and at least 95 % ee can be achieved for the addition of dimethyl malonate to cycloalkenyl acetates by using a palladium complex of the new phosphanyldihydrooxazole ligand L as a catalyst (see scheme). The ligand L can be synthesized from commercially available trans 4‐hydroxy‐L‐proline in four steps. BOC=tert‐butoxycarbonyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990917)38:18<2750::AID-ANIE2750>3.0.CO;2-5