Sesquiterpene lactones from Neurolaena oaxacana

Twelve sesquiterpene lactones, two new (1 and 2) and 10 known neurolenin-type germacranolides and furanoheliangolides (3-12) were isolated from Neurolaena oaxacana, and their structures were elucidated by NMR and GC-MS analysis. The chemotaxonomic importance of these findings is discussed. As N. lob...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1093-1095
Hauptverfasser:	Passreiter, C.M, Sandoval-Ramirez, J, Wright, C.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Asteraceae Biological and medical sciences chemical constituents of plants chemical structure chemotaxonomy dysentery Entamoeba histolytica franoheliangolides General pharmacology Giardia intestinalis Giardia lamblia leaves Medical sciences medicinal plants medicinal properties neurolaena cobanensis Neurolaena oaxacana neurolenin B neurolenin C neurolenin D neurolenin-type germacranolides Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments section brevipalea series radiata sesquiterpene lactones sesquiterpenoid lactones spectral analysis
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Zusammenfassung:	Twelve sesquiterpene lactones, two new (1 and 2) and 10 known neurolenin-type germacranolides and furanoheliangolides (3-12) were isolated from Neurolaena oaxacana, and their structures were elucidated by NMR and GC-MS analysis. The chemotaxonomic importance of these findings is discussed. As N. lobata is used against dysenteries, neurolenin B (4) and a mixture of the neurolenins C (5) and D (6) were tested against Entamoeba histolytica and Giardia intestinalis.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np990038t