Photomodulation of the Conformation of Cyclic Peptides with Azobenzene Moieties in the Peptide Backbone

Photomodulation of the Conformation of Cyclic Peptides with Azobenzene Moieties in the Peptide Backbone

The cis⇌trans photoisomerization of the azobenzene building block 4‐(4‐aminophenylazo)benzoic acid incorporated in a cyclic peptide (see scheme) facilitated a two‐state transition of the peptide chain from a rigid constrained conformation in the trans isomer into the largely free conformational spac...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-09, Vol.38 (18), p.2771-2774
Hauptverfasser: Behrendt, Raymond, Renner, Christian, Schenk, Michaela, Wang, Fengqi, Wachtveitl, Josef, Oesterhelt, Dieter, Moroder, Luis
Format: Artikel
Sprache:eng
Schlagworte:
Azo compounds
Conformation analysis
Isomerizations
Peptides
Solid-phase synthesis
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Beschreibung
Zusammenfassung:The cis⇌trans photoisomerization of the azobenzene building block 4‐(4‐aminophenylazo)benzoic acid incorporated in a cyclic peptide (see scheme) facilitated a two‐state transition of the peptide chain from a rigid constrained conformation in the trans isomer into the largely free conformational space of the cis isomer.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990917)38:18<2771::AID-ANIE2771>3.0.CO;2-W