Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening

Assay miniaturization applicable across a wide range of target classes, along with automation and process integration, are well-recognized goals for ultra-high-throughput screening on an industrial scale. This report summarizes the implementation of fluorescence resonance energy transfer (FRET)-base...

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Veröffentlicht in:	Drug Discovery Today 1999-08, Vol.4 (8), p.363-369
Hauptverfasser:	Mere, Lora, Bennett, Todd, Coassin, Peter, England, Paul, Hamman, Brian, Rink, Timothy, Zimmerman, Susan, Negulescu, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	3456-well plate Analysis Automation Biological and medical sciences Cell-based assays Fluorescence FRET General pharmacology HTS Medical sciences Microfluidics Miniaturization Pharmacology. Drug treatments UHTSS
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Assay miniaturization applicable across a wide range of target classes, along with automation and process integration, are well-recognized goals for ultra-high-throughput screening on an industrial scale. This report summarizes the implementation of fluorescence resonance energy transfer (FRET)-based biochemical and cell-based assays in 3456-well NanoWell ™ assay plates using key components of Aurora's ultra-high-throughput screening system.
ISSN:	1359-6446 1878-5832
DOI:	10.1016/S1359-6446(99)01377-X