Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice

Highlights • TAC, not BMV, reduced scratching and improved dermatitis in Dfb-NC/Nga mice. • Strongest steroid CBP reduced scratching and improved dermatitis in Dfb-NC/Nga mice. • The therapeutic efficacies of CBP and TAC on AD-like symptoms were similar. • Early antipruritic effects of TAC and CBP a...

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Veröffentlicht in:	Journal of dermatological science 2017-04, Vol.86 (1), p.54-62
Hauptverfasser:	Noguchi, Atsushi, Tominaga, Mitsutoshi, Takahashi, Nobuaki, Matsuda, Hironori, Kamata, Yayoi, Umehara, Yoshie, Ko, Kyi Chan, Suga, Yasushi, Ogawa, Hideoki, Takamori, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Animals Atopic dermatitis Betamethasone Valerate - administration & dosage Betamethasone Valerate - therapeutic use Clobetasol - administration & dosage Clobetasol - therapeutic use Corticosteroid Cytokines - metabolism Dermatitis, Atopic - drug therapy Dermatitis, Atopic - etiology Dermatology Dermatophagoides farinae - immunology Disease Models, Animal Emollients - administration & dosage Emollients - therapeutic use Epidermal nerve fiber Epidermis - drug effects Epidermis - metabolism Epidermis - pathology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Male Mast Cells - metabolism Mice Ointments - administration & dosage Ointments - therapeutic use Petrolatum - administration & dosage Petrolatum - therapeutic use Pruritus Pruritus - drug therapy Tacrolimus Tacrolimus - administration & dosage Tacrolimus - therapeutic use Treatment Outcome Ubiquitin Thiolesterase - metabolism
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Zusammenfassung:	Highlights • TAC, not BMV, reduced scratching and improved dermatitis in Dfb-NC/Nga mice. • Strongest steroid CBP reduced scratching and improved dermatitis in Dfb-NC/Nga mice. • The therapeutic efficacies of CBP and TAC on AD-like symptoms were similar. • Early antipruritic effects of TAC and CBP are unrelated to epidermal innervation.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.12.015