Non-directed aromatic C-H amination: catalytic and mechanistic studies enabled by Pd catalyst and reagent design

This manuscript describes the systematic development of pyridine-type ligands, which promote the Pd catalyzed, non-directed amination of benzene in combination with novel, hydroxylamine-based electrophilic amination reagents. DFT calculations and mechanistic experiments provide insights into the factors influencing the arene C-H amination protocol. The systematic development of pyridine-type ligands and electrophilic amination reagents is described, which promote aromatic Pd catalyzed, non-directed C-H aminations.