miRNA-144 induces microglial autophagy and inflammation following intracerebral hemorrhage

Highlights • ICH promoted miRNA-144 expression but downregulated mTOR expression. • Upregulation of mTOR attenuated microglial autophagy and inflammation in ICH. • Downregulation of miRNA-144 improved neurological functions in ICH mice. • miRNA-144 represented a promising therapeutical strategy for...

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Veröffentlicht in:	Immunology letters 2017-02, Vol.182, p.18-23
Hauptverfasser:	Yu, Anyong, Zhang, Tianxi, Zhong, Wenyi, Duan, Haizhen, Wang, Song, Ye, Peng, Wang, Juan, Zhong, Shanchuan, Yang, Zhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autophagy Autophagy - genetics Cerebral Hemorrhage - complications Cerebral Hemorrhage - etiology Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - pathology Gene Expression ICH Inflammation Inflammation - etiology Inflammation - metabolism Inflammation - pathology Mice Microglia Microglia - metabolism Microglia - pathology Microglia - ultrastructure MicroRNAs - genetics miRNA-144 TOR Serine-Threonine Kinases - metabolism
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Zusammenfassung:	Highlights • ICH promoted miRNA-144 expression but downregulated mTOR expression. • Upregulation of mTOR attenuated microglial autophagy and inflammation in ICH. • Downregulation of miRNA-144 improved neurological functions in ICH mice. • miRNA-144 represented a promising therapeutical strategy for ICH.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.01.002