Amine functionalised hydroxyapatite nanoparticles for anti-angiogenesis gene therapy of breast cancer

A functionalised hydroxyapatite (HAP) nanoparticles based drug delivery system (DDS) [anti-angiogenesis (ANG)/amine functionalised HAP (NHAP) nanoparticles] composed of HAP nanoparticles and therapeutic ANG plasmid was successfully developed for gene therapy of breast cancer. ANG/NHAP nanoparticles...

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Veröffentlicht in:	Micro & nano letters 2016-08, Vol.11 (8), p.416-419
Hauptverfasser:	Xu, Hongjie, Wei, Dajun, Gai, Xiaodong, Jiang, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	amine functionalised hydroxyapatite nanoparticles Amines ANG‐NHAP nanoparticle low‐cytotoxicity antiangiogenesis gene therapy antiangiogenesis‐amine functionalised HAP nanoparticles Breast breast cancer gene therapy Ca10(PO4)6(OH)2 Cancer cellular assays cellular biophysics drug delivery systems functionalised hydroxyapatite nanoparticle‐based drug delivery system Gene therapy Hydroxyapatite MCF‐7 cells nanomedicine Nanoparticles Nanostructure plasmid condensation sodium compounds therapeutic ANG plasmid Toxicity
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Beschreibung
Zusammenfassung:	A functionalised hydroxyapatite (HAP) nanoparticles based drug delivery system (DDS) [anti-angiogenesis (ANG)/amine functionalised HAP (NHAP) nanoparticles] composed of HAP nanoparticles and therapeutic ANG plasmid was successfully developed for gene therapy of breast cancer. ANG/NHAP nanoparticles displayed nano-sized diameter of around 50 nm and effective plasmid condensation ability. Cellular assays on MCF-7 cells further confirmed high transfection and ANG efficacy as well as low cytotoxicity of ANG/NHAP nanoparticles, which suggested that ANG/NHAP nanoparticles might be a safe and effective DDS for potential breast cancer gene therapy.
ISSN:	1750-0443 1750-0443
DOI:	10.1049/mnl.2016.0078