Myclobutanil worsens nonalcoholic fatty liver disease: An in vitro study of toxicity and apoptosis on HepG2 cells

•Hepatic toxicity of myclobutanil exacerbates fatty acid-induced steatosis.•Myclobutanil reduces viability of HepG2 cells to

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Veröffentlicht in:	Toxicology letters 2016-11, Vol.262, p.100-104
Hauptverfasser:	Stellavato, Antonietta, Lamberti, Monica, Pirozzi, Anna Virginia Adriana, de Novellis, Francesca, Schiraldi, Chiara
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Ascomycetes Basidiomycetes bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-X Protein - metabolism Cell Death - drug effects Commodities Conazole fungicide Cytochromes c - metabolism Drinking water Fatty Acids - metabolism Fungi Fungicides Fungicides, Industrial - toxicity Hep G2 Cells Hepatocytes - drug effects Hepatoxicity HepG2 cells Humans L-Lactate Dehydrogenase - metabolism Lipid Metabolism - drug effects Liver Myclobutanil Myeloid Cell Leukemia Sequence 1 Protein - metabolism Nitriles - toxicity Non-alcoholic Fatty Liver Disease - chemically induced Non-alcoholic Fatty Liver Disease - pathology Nonalcoholic fatty liver disease Organs Toxicity Toxicology Triazoles - toxicity
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Zusammenfassung:	•Hepatic toxicity of myclobutanil exacerbates fatty acid-induced steatosis.•Myclobutanil reduces viability of HepG2 cells to
ISSN:	0378-4274 1879-3169
DOI:	10.1016/j.toxlet.2016.09.013