A new multicomponent reaction for direct synthesis of primary γ-nitroamides

A new multicomponent reaction for direct synthesis of primary γ-nitroamides

A new multicomponent reaction for direct synthesis of γ-nitroamides promoted by ammonium carbonate was developed. A series of γ-nitroamides were synthesized in 35–93% yield from Meldrum's acid, aromatic or aliphatic aldehydes, nitromethane and ammonium carbonate. A mechanistic pathway was propo...

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Veröffentlicht in:RSC advances 2016-01, Vol.6 (100), p.98427-98433
Hauptverfasser: Montes D'Oca, Caroline R., da Silva, Jessica C., Guedes, Esthefani P., Montes D'Oca, Marcelo G., Santos, Leonardo S., Nachtigall, Fabiane M., Russowsky, Dennis
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Carbonates
Ionization
Mass spectrometry
Nitromethane
Pathways
Synthesis
Synthesis (chemistry)
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Zusammenfassung:A new multicomponent reaction for direct synthesis of γ-nitroamides promoted by ammonium carbonate was developed. A series of γ-nitroamides were synthesized in 35–93% yield from Meldrum's acid, aromatic or aliphatic aldehydes, nitromethane and ammonium carbonate. A mechanistic pathway was proposed based on electrospray ionization mass spectrometry (ESI/MS) experiments.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA22141F