Ligand-free Cu-catalyzed O-arylation of aliphatic diols

Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (81), p.66104-66108
Hauptverfasser:	Zheng, Yufen, Zou, Wenxing, Luo, Laichun, Chen, Jiabei, Lin, Songwen, Sun, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Aromatic compounds Catalysts Chemical reactions Copper Diols Iodides Synthesis
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description	Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.
doi_str_mv	10.1039/C5RA12529D
format	Article
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source	Royal Society Of Chemistry Journals
subjects	Aliphatic compounds Aromatic compounds Catalysts Chemical reactions Copper Diols Iodides Synthesis
title	Ligand-free Cu-catalyzed O-arylation of aliphatic diols
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