Ligand-free Cu-catalyzed O-arylation of aliphatic diols

Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	RSC advances 2015-01, Vol.5 (81), p.66104-66108
Hauptverfasser:	Zheng, Yufen, Zou, Wenxing, Luo, Laichun, Chen, Jiabei, Lin, Songwen, Sun, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Aromatic compounds Catalysts Chemical reactions Copper Diols Iodides Synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.
ISSN:	2046-2069 2046-2069
DOI:	10.1039/C5RA12529D