Semi-quantitative analysis of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: a first-line tool

Objective The aim of this study was the assessment of semi-quantified salivary gland dynamic scintigraphy (SGdS) parameters independently and in an integrated way in order to predict primary Sjögren’s syndrome (pSS). Materials and methods Forty-six consecutive patients (41 females; age 61 ± 11 years...

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Veröffentlicht in:Clinical oral investigations 2017-09, Vol.21 (7), p.2389-2395
Hauptverfasser: Angusti, Tiziana, Pilati, Emanuela, Parente, Antonella, Carignola, Renato, Manfredi, Matteo, Cauda, Simona, Pizzigati, Elena, Dubreuil, Julien, Giammarile, Francesco, Podio, Valerio, Skanjeti, Andrea
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Sprache:eng
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Zusammenfassung:Objective The aim of this study was the assessment of semi-quantified salivary gland dynamic scintigraphy (SGdS) parameters independently and in an integrated way in order to predict primary Sjögren’s syndrome (pSS). Materials and methods Forty-six consecutive patients (41 females; age 61 ± 11 years) with sicca syndrome were studied by SGdS after injection of 200 MBq of pertechnetate. In sixteen patients, pSS was diagnosed, according to American-European Consensus Group criteria (AECGc). Semi-quantitative parameters (uptake (UP) and excretion fraction (EF)) were obtained for each gland. ROC curves were used to determine the best cut-off value. The area under the curve (AUC) was used to estimate the accuracy of each semi-quantitative analysis. To assess the correlation between scintigraphic results and disease severity, semi-quantitative parameters were plotted versus Sjögren’s syndrome disease activity index (ESSDAI). A nomogram was built to perform an integrated evaluation of all the scintigraphic semi-quantitative data. Results Both UP and EF of salivary glands were significantly lower in pSS patients compared to those in non-pSS ( p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-016-2034-6