Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway

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Veröffentlicht in:Biomedicine & pharmacotherapy 2017-03, Vol.87, p.145-152
Hauptverfasser: Tang, Dan, Chen, Qi-Bin, Xin, Xue-Lei, Aisa, Haji-Akber
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container_start_page 145
container_title Biomedicine & pharmacotherapy
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creator Tang, Dan
Chen, Qi-Bin
Xin, Xue-Lei
Aisa, Haji-Akber
description Graphical abstract
doi_str_mv 10.1016/j.biopha.2016.12.058
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subjects Animals
Anti-diabetic activity
Cells, Cultured
Diabetes
Diterpenes - isolation & purification
Diterpenes - pharmacology
Glucose - agonists
Glucose - metabolism
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Internal Medicine
Medical Education
Nigella
Norditerpenoid alkaloids
Phosphatidylinositol 3-Kinases - metabolism
PI3K/Akt signaling pathway
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Protein tyrosine phosphatase 1B
Proto-Oncogene Proteins c-akt - metabolism
Rats
Seeds
Signal Transduction - drug effects
Signal Transduction - physiology
title Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway
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