Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-03, Vol.87, p.145-152
Hauptverfasser:	Tang, Dan, Chen, Qi-Bin, Xin, Xue-Lei, Aisa, Haji-Akber
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-diabetic activity Cells, Cultured Diabetes Diterpenes - isolation & purification Diterpenes - pharmacology Glucose - agonists Glucose - metabolism Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Internal Medicine Medical Education Nigella Norditerpenoid alkaloids Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt signaling pathway Plant Extracts - isolation & purification Plant Extracts - pharmacology Protein tyrosine phosphatase 1B Proto-Oncogene Proteins c-akt - metabolism Rats Seeds Signal Transduction - drug effects Signal Transduction - physiology
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