Molecular Markers of Antimicrobial Resistance in Methicillin-Resistant Staphylococcus aureus SCCmec IV Presenting Different Genetic Backgrounds

Methicillin-resistant Staphylococcus aureus (MRSA) carrying SCC mec type IV has emerged in hospitals worldwide. The aim of this study was to evaluate phenotypic and molecular characteristics of antimicrobial resistance in MRSA SCC mec IV isolates, presenting different genetic backgrounds, isolated f...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2016-12, Vol.22 (8), p.7-706
Hauptverfasser:	de Matos, Pricilla Dias Moura, de Oliveira, Tamara Lopes Rocha, Cavalcante, Fernanda Sampaio, Ferreira, Dennis Carvalho, Iorio, Natália Lopes Pontes, Pereira, Eliezer Menezes, Chamon, Raiane Cardoso, dos Santos, Kátia Regina Netto
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Typing Techniques Brazil - epidemiology DNA Topoisomerase IV - genetics DNA Topoisomerase IV - metabolism Drug resistance Drug Resistance, Multiple, Bacterial - genetics Epidemiology Gene Expression Regulation, Bacterial Genotype & phenotype Hospitals Humans Lincosamides - pharmacology Macrolides - pharmacology Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - growth & development Methicillin-Resistant Staphylococcus aureus - isolation & purification Methionine Sulfoxide Reductases - genetics Methionine Sulfoxide Reductases - metabolism Methyltransferases - genetics Methyltransferases - metabolism Microbial Sensitivity Tests Molecular Epidemiology Multidrug resistant organisms Mutation Nosocomial infections Public health Quinolones - pharmacology Staphylococcal Infections - drug therapy Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus infections Streptogramin B - pharmacology
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Zusammenfassung:	Methicillin-resistant Staphylococcus aureus (MRSA) carrying SCC mec type IV has emerged in hospitals worldwide. The aim of this study was to evaluate phenotypic and molecular characteristics of antimicrobial resistance in MRSA SCC mec IV isolates, presenting different genetic backgrounds, isolated from hospitals in Rio de Janeiro. The antimicrobial resistance of 128 S. aureus type IV isolates from 11 hospitals was characterized by the disk diffusion test and minimum inhibitory concentration (MIC) test. Mutations in par C gene, which encodes ciprofloxacin resistance, and genes associated with macrolide–lincosamide–streptogramin B (MLS b ) resistance were also investigated. MRSA isolates belonging to USA400/ST1 (60 isolates), USA800/ST5 (40), USA1100/ST30 (13), and other 11 (15) lineages were mainly resistant to erythromycin (68%), ciprofloxacin (56%), and clindamycin (50%). The highest antimicrobial resistance rates were found among USA400 isolates ( p
ISSN:	1076-6294 1931-8448
DOI:	10.1089/mdr.2015.0255