Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody–drug conjugates because carnosine acts as an ionophore for Cu 2+ or Zn 2+ , altering the metallostasis of cancer cells, leading to their death....

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Veröffentlicht in:MedChemComm 2016-01, Vol.7 (12), p.2364-2367
Hauptverfasser: Accardo, Antonella, Del Zoppo, Luisa, Morelli, Giancarlo, Condorelli, Daniele F., Barresi, Vincenza, Musso, Nicolò, Spampinato, Giorgia, Bellia, Francesco, Tabbì, Giovanni, Rizzarelli, Enrico
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Sprache:eng
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Zusammenfassung:Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody–drug conjugates because carnosine acts as an ionophore for Cu 2+ or Zn 2+ , altering the metallostasis of cancer cells, leading to their death.
ISSN:2040-2503
2040-2511
DOI:10.1039/C6MD00461J