Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice

Highlights • Hemokinin-1 exerts anxiolytic and anti-depressant-like actions in mouse models. • Stress-induced neuronal activation is decreased in hemokinin-1-deficient mice. • Deleting and blocking the NK-1 receptors decrease depression-like behaviour. • Hemokinin-1 regulates stress/depression via u...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-01, Vol.59, p.219-232
Hauptverfasser:	Borbély, Éva, Hajna, Zsófia, Nabi, Liza, Scheich, Bálint, Tékus, Valéria, László, Kristóf, Ollmann, Tamás, Kormos, Viktória, Gaszner, Balázs, Karádi, Zoltán, Lénárd, László, Paige, Christopher J, Quinn, John P, Szolcsányi, János, Pintér, Erika, Keeble, Julie, Berger, Alexandra, Helyes, Zsuzsanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anhedonia Animals Anti-Anxiety Agents - pharmacology Anxiety - genetics Anxiety - psychology Behavior Depression - genetics Depression - psychology Elevated plus maze test Food Preferences Forced swim test Fos immunohistochemistry Genes, fos Hindlimb Suspension Light-dark box test Male Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Open field test Protein Precursors - genetics Protein Precursors - physiology Psychiatry Receptors, Neurokinin-1 - genetics Substance P - genetics Sucrose preference test Tachykinins Tachykinins - genetics Tachykinins - physiology Tail suspension test
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Zusammenfassung:	Highlights • Hemokinin-1 exerts anxiolytic and anti-depressant-like actions in mouse models. • Stress-induced neuronal activation is decreased in hemokinin-1-deficient mice. • Deleting and blocking the NK-1 receptors decrease depression-like behaviour. • Hemokinin-1 regulates stress/depression via unknown target-mediated mechanisms.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.09.004