Localized pancreatic cancer with positive peritoneal cytology as a sole manifestation of metastatic disease: a single institution experience

Abstract Background Pancreatic cancer patients with positive peritoneal cytology (PPC) as a sole metastatic site are poorly characterized. Whether they behave similarly to other stage IV patients is unknown. Methods Patients with stage IV disease at our institution between 2003-2013 were identified....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of surgery 2017-01, Vol.213 (1), p.94-99
Hauptverfasser:	Oh, Stephen Y., MBBS, BSc, Edwards, Alicia, MBA, Mandelson, Margaret T., PhD, Hahn, Hejin, MD, Alseidi, Adnan, MD, Biehl, Thomas, MD, Kozarek, Richard A., MD, Rocha, Flavio G., MD, Helton, Scott, MD, Picozzi, Vincent J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - mortality Adenocarcinoma - secondary Adenocarcinoma - therapy Adult Aged Aged, 80 and over Cancer staging Cancer therapies Cellular biology Chemoradiation Chemoradiotherapy Chemotherapy Disease progression Disease-Free Survival Female Humans Laparoscopy Male Medical imaging Metastasis Middle Aged Neoplasm Staging Pancreatic cancer Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Patients Peritoneal washing Peritoneum - pathology Retrospective Studies Surgeons Surgery Survival Survival analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Background Pancreatic cancer patients with positive peritoneal cytology (PPC) as a sole metastatic site are poorly characterized. Whether they behave similarly to other stage IV patients is unknown. Methods Patients with stage IV disease at our institution between 2003-2013 were identified. Inclusion criteria for PPC cohort were PPC at laparoscopy and no laparoscopic/radiographic evidence of metastasis. Patients with gross metastasis had laparoscopic/radiographic evidence of metastasis. Results Among 308 patients, 43 patients had PPC and 265 gross metastasis. PPC cohort: 3 (7%) resectable, 8 (19%) borderline resectable, and 32 (74%) unresectable tumor. Disease progression occurred in 37 (86%). 16/43 (37%) also received local therapy (1 surgery, 15 chemoradiation). PPC vs. gross metastasis cohort differed as follows: baseline Ca 19-9 (440 vs. 1904 IU/mL, p
ISSN:	0002-9610 1879-1883
DOI:	10.1016/j.amjsurg.2016.04.008