Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice

Highlights • ICV administration of STZ induced behavioral abnormalities in mice after 24 h. • These effects were associated with abnormal mitochondrial function in hippocampus. • STZ treatment increased the expression of innate immunity genes in hippocampus. • Sterile inflammatory responses may play...

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Veröffentlicht in:	Neuroscience 2017-01, Vol.340, p.373-383
Hauptverfasser:	Amiri, Shayan, Haj-Mirzaiain, Arya, Momeny, Majid, Amini-Khoei, Hossein, Rahimi-Balaei, Maryam, Poursaman, Simin, Rastegar, Mojgan, Nikoui, Vahid, Mokhtari, Tahmineh, Ghazi-Khansari, Mahmoud, Hosseini, Mir-Jamal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anxiety Anxiety - immunology Anxiety - pathology Cytosol - metabolism Cytosol - pathology depression Depression - immunology Depression - pathology Disease Models, Animal Hippocampus - immunology Hippocampus - pathology Immunity, Innate - genetics Immunity, Innate - physiology innate immunity Male Mice mitochondria Mitochondria - immunology Mitochondria - pathology Neurology Nitric Oxide - metabolism Oxidative Stress - physiology Phospholipases A2 - metabolism sterile inflammation Streptozocin streptozotocin (STZ)
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Zusammenfassung:	Highlights • ICV administration of STZ induced behavioral abnormalities in mice after 24 h. • These effects were associated with abnormal mitochondrial function in hippocampus. • STZ treatment increased the expression of innate immunity genes in hippocampus. • Sterile inflammatory responses may play a role in the behavioral effects of STZ.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.11.003