Ds-HMGB1 and Fr-HMGB Induce Depressive Behavior through Neuroinflammation in Contrast to Nonoxid-HMGB1

Highlights • Both ds-HMGB1 and fr-HMGB1 induce depressive behavior. • The depressive behavior induced by ds-HMGB1 is related to TLR4 activation and a subsequent TNF-α increase. • Fr-HMGB1 evokes depressive behavior through TLR4, RAGE and CXCR4, which are related to TNF-α induction. • Nonoxid-HMGB1 c...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-01, Vol.59, p.322-332
Hauptverfasser:	Lian, Yong-Jie, Gong, Hong, Wu, Teng-Yun, Su, Wen-Jun, Zhang, Yi, Yang, Yuan-Yuan, Peng, Wei, Zhang, Ting, Zhou, Jiang-Rui, Jiang, Chun-Lei, Wang, Yun-Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anhedonia Animals Depression Depression - chemically induced Depression - psychology Hindlimb Suspension Hippocampus - drug effects Hippocampus - metabolism HMGB1 protein HMGB1 Protein - chemistry HMGB1 Protein - genetics HMGB1 Protein - pharmacology Humans Inflammation - chemically induced Inflammation - psychology Injections, Intraperitoneal Injections, Intraventricular Male Mice Mice, Inbred BALB C Motor Activity Myelin basic protein Oxidation-Reduction Psychiatry Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - pharmacology Redox forms Stress, Psychological - psychology TNF-α Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • Both ds-HMGB1 and fr-HMGB1 induce depressive behavior. • The depressive behavior induced by ds-HMGB1 is related to TLR4 activation and a subsequent TNF-α increase. • Fr-HMGB1 evokes depressive behavior through TLR4, RAGE and CXCR4, which are related to TNF-α induction. • Nonoxid-HMGB1 cannot induce depressive behavior or a central TNF-α increase.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.09.017