AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord

AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord

Highlights • The expression patterns of AP-2 family in developing spinal cord are systematically summarized for the first time. • The regionalized expression patterns of AP-2 family genes are highly conserved. • Distinct functions of AP-2 factors in dorsal interneuron specification are disclosed in...

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Veröffentlicht in:Neuroscience 2017-01, Vol.340, p.232-242
Hauptverfasser: Xu, Xiaofeng, Liu, Zijing, Huang, Hao, Zheng, Kang, Hu, Xuemei, Zhang, Zunyi, Qiu, Mengsheng
Format: Artikel
Sprache:eng
Schlagworte:
Animals
AP-2
Avian Proteins - genetics
Avian Proteins - metabolism
Chick Embryo
dorsal interneuron specification
Electroporation
Fluorescent Antibody Technique
in ovo electroporation
In Situ Hybridization
Interneurons - cytology
Interneurons - metabolism
Mice, Inbred C57BL
Neurogenesis - physiology
Neurology
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - metabolism
Transcription Factor AP-2 - genetics
Transcription Factor AP-2 - metabolism
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Zusammenfassung:Highlights • The expression patterns of AP-2 family in developing spinal cord are systematically summarized for the first time. • The regionalized expression patterns of AP-2 family genes are highly conserved. • Distinct functions of AP-2 factors in dorsal interneuron specification are disclosed in chick embryos.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.10.055