TNF Alpha Stimulation Increases Dental Pulp Stem Cell Migration In Vitro Through Integrin Alpha 6 Subunit Upregulation

Highlights • Tumor necrosis factor-α (TNF-a) plays a role in migration of human dental pulp stem cells. • TNF-α at a concentration of 50 ng/ml enhances hDPSC migration in vitro. • Intgerin α6 expression plays a role in chemotactic migration of TNF-α treated cells. • SiRNA treatment for reducing integrin α6 expression in hDPSCs causes a decrease in their migration potential and the cells lose their sense of directionality. • Cytoskeletal changes in TNF-α treated group of cells are in line with the migratory phenotype in hDPSCs.