Ghrelin upregulates PepT1 activity in the small intestine epithelium of rats with sepsis

Highlights • Reveal the effect of ghrelin on the survival rate of rats with sepsis. • Confirmed the relationship between ghrelin treatment and inflammatory response in intestinal epithelial cells of rats with sepsis. • Found that ghrelin treatment contributes to the physiological role of PepT1 in in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-02, Vol.86, p.669-676
Hauptverfasser:	Liu, Jingquan, Shi, Bin, Shi, Kai, Ma, Guoguang, Zhang, Hongze, Lou, Xiaoli, Liu, Hongxiang, Wan, Shengxia, Liang, Dongyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cecal ligation and puncture Disease Models, Animal Ghrelin Ghrelin - metabolism Inflammatory response Interleukin-1beta - metabolism Internal Medicine Intestinal Mucosa - metabolism Intestine, Small - metabolism Ligation - methods Male Medical Education PepT1 Peptide Transporter 1 Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Sepsis Sepsis - metabolism Symporters - metabolism Tumor Necrosis Factor-alpha - metabolism Up-Regulation - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Reveal the effect of ghrelin on the survival rate of rats with sepsis. • Confirmed the relationship between ghrelin treatment and inflammatory response in intestinal epithelial cells of rats with sepsis. • Found that ghrelin treatment contributes to the physiological role of PepT1 in intestinal epithelial cells of rats with sepsis.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2016.12.026