Acute promyelocytic leukaemia with a novel translocation t(16;17)(q12;p13): a case report

Acute promyelocytic leukaemia with a novel translocation t(16;17)(q12;p13): a case report

Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who was negative for P...

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Veröffentlicht in:Malaysian journal of pathology 2016-12, Vol.38 (3), p.311-313
Hauptverfasser: Bhat, H, Geelani, S, Rashid, M, Bhat, T, Qadri, M, Bashir N, N, Manzoor, F, Bhat, S, Rather, F, Rasool, J
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Chromosomes, Human, Pair 16 - genetics
Chromosomes, Human, Pair 17 - genetics
Humans
Karyotyping
Leukemia, Promyelocytic, Acute - genetics
Male
Real-Time Polymerase Chain Reaction
Translocation, Genetic
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Zusammenfassung:Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16;17). To the best of our knowledge this is the first case report of APML responsive to ATRA with such a translocation.
ISSN:0126-8635