Circulating Tumor Cells in a Phase 3 Study of Docetaxel and Prednisone with or without Lenalidomide in Metastatic Castration-resistant Prostate Cancer
Abstract Elevated circulating tumor cell (CTC) blood levels (≥5 cells/7.5 ml) convey a negative prognosis in metastatic castration-resistant prostate cancer but their prognostic significance in patients receiving chemotherapy is uncertain. The association between CTC counts (at baseline or after tre...
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Veröffentlicht in: | European urology 2017-02, Vol.71 (2), p.168-171 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Elevated circulating tumor cell (CTC) blood levels (≥5 cells/7.5 ml) convey a negative prognosis in metastatic castration-resistant prostate cancer but their prognostic significance in patients receiving chemotherapy is uncertain. The association between CTC counts (at baseline or after treatment), overall survival (OS), and response to docetaxel with lenalidomide was evaluated in a 208-patient subset from the MAINSAIL trial, which compared docetaxel-prednisone-lenalidomide and docetaxel-prednisone-placebo in metastatic castration-resistant prostate cancer patients. Baseline CTCs were < 5 cells/7.5 ml blood in 87 (42%) patients and ≥5 cells/7.5 ml in 121 (58%) patients. Neither tumor response nor prostate-specific antigen response correlated with baseline CTCs. However, CTC count ≥5 cells/7.5 ml was significantly associated with lower OS (hazard ratio: 3.23, p = 0.0028). Increases in CTCs from |
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ISSN: | 0302-2838 1873-7560 |
DOI: | 10.1016/j.eururo.2016.07.051 |