Inotropic support against early brain injury improves cerebral hypoperfusion and outcomes in a murine model of subarachnoid hemorrhage

Highlights • Acute cardiac support with DOB improves hypoperfusion early after SAH. • The DOB effects can lead to lower incidence of DCI and better functional outcomes. • The DOB-mediated outcomes were attenuated by a HIF inhibitor 2ME2 pretreatment. • Neurocardiac protection with DOB can promote re...

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Veröffentlicht in:	Brain research bulletin 2017-04, Vol.130, p.18-26
Hauptverfasser:	Mutoh, Tomoko, Mutoh, Tatsushi, Nakamura, Kazuhiro, Sasaki, Kazumasu, Tatewaki, Yasuko, Ishikawa, Tatsuya, Taki, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Brain Injuries - complications Brain Injuries - physiopathology Brain Injuries - prevention & control Cardiotonic Agents - administration & dosage Cerebral blood flow Cerebral Cortex - blood supply Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Delayed cerebral ischemia Disease Models, Animal Dobutamine Dobutamine - administration & dosage Early brain injury Hypoxia-Inducible Factor 1 - administration & dosage Male Mice, Inbred C57BL Neurology Neuroprotective Agents - administration & dosage Subarachnoid hemorrhage Subarachnoid Hemorrhage - chemically induced Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - physiopathology Subarachnoid Hemorrhage - prevention & control
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Zusammenfassung:	Highlights • Acute cardiac support with DOB improves hypoperfusion early after SAH. • The DOB effects can lead to lower incidence of DCI and better functional outcomes. • The DOB-mediated outcomes were attenuated by a HIF inhibitor 2ME2 pretreatment. • Neurocardiac protection with DOB can promote recovery from post-SAH EBI.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2016.12.009