Thalidomide in the treatment of leprosy

Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition...

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Veröffentlicht in:	Microbes and Infection 2002-09, Vol.4 (11), p.1193-1202
Hauptverfasser:	Teo, Steve K., Resztak, Ken E., Scheffler, Michael A., Kook, Karin A., Zeldis, Jerry B., Stirling, David I., Thomas, Steve D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Biological and medical sciences Drug Therapy, Combination Erythema Nodosum - drug therapy Erythema Nodosum - pathology Erythema nodosum leprosum Human bacterial diseases Humans Incidence Infectious diseases Leprostatic Agents - therapeutic use Leprosy Leprosy - drug therapy Leprosy - pathology Leprosy - transmission Leprosy, Lepromatous - drug therapy Leprosy, Lepromatous - pathology Medical sciences Models, Molecular Mycobacterium leprae - pathogenicity Pharmacology. Drug treatments Thalidomide Thalidomide - adverse effects Thalidomide - pharmacokinetics Thalidomide - pharmacology Thalidomide - therapeutic use Tropical bacterial diseases Tumor Necrosis Factor-alpha - metabolism Type 2 reaction
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Beschreibung
Zusammenfassung:	Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-α produced by monocytes.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/S1286-4579(02)01645-3