Genome-wide association study of Parkinson's disease in East Asians

Genome-wide association study of Parkinson's disease in East Asians

Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has been done in Han Chinese, which make up nearly a fifth of the world population. We conducted the first Han Chinese GWAS analysing a total of 22,729 subjects (5,125 PD...

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Veröffentlicht in:Human molecular genetics 2017-01, Vol.26 (1), p.226-232
Hauptverfasser: Foo, Jia Nee, Tan, Louis C, Irwan, Ishak D, Au, Wing-Lok, Low, Hui Qi, Prakash, Kumar-M, Ahmad-Annuar, Azlina, Bei, Jinxin, Chan, Anne Yy, Chen, Chiung Mei, Chen, Yi-Chun, Chung, Sun Ju, Deng, Hao, Lim, Shen-Yang, Mok, Vincent, Pang, Hao, Pei, Zhong, Peng, Rong, Shang, Hui-Fang, Song, Kyuyoung, Tan, Ai Huey, Wu, Yih-Ru, Aung, Tin, Cheng, Ching-Yu, Chew, Fook Tim, Chew, Soo-Hong, Chong, Siow-Ann, Ebstein, Richard P, Lee, Jimmy, Saw, Seang-Mei, Seow, Adeline, Subramaniam, Mythily, Tai, E-Shyong, Vithana, Eranga N, Wong, Tien-Yin, Heng, Khai Koon, Meah, Wee-Yang, Khor, Chiea Chuen, Liu, Hong, Zhang, Furen, Liu, Jianjun, Tan, Eng-King
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarkers - analysis
Biomarkers - metabolism
Case-Control Studies
Ethnic Groups - genetics
Far East - epidemiology
Female
Genetic Loci - genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Male
Meta-Analysis as Topic
Middle Aged
Parkinson Disease - epidemiology
Parkinson Disease - genetics
Polymorphism, Single Nucleotide - genetics
Risk Factors
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Beschreibung
Zusammenfassung:Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has been done in Han Chinese, which make up nearly a fifth of the world population. We conducted the first Han Chinese GWAS analysing a total of 22,729 subjects (5,125 PD cases and 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China and Taiwan. We performed imputation, merging and logistic regression analyses of 2,402,394 SNPs passing quality control filters in 779 PD cases, 13,227 controls, adjusted for the first three principal components. 90 SNPs with association P 
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddw379